Protein carbonyl products, malondialdehyde, glutathione and vitamins C/E of breast cancer patients subjected to chemotherapy

INTRODUCTION: Various endogenous and exogenous processes contribute to the production of oxidative stress, which anticancer drugs may be one. This study aimed at evaluating effect breast cancer chemotherapy on stress. MATERIAL AND METHODS: Oxidative markers antioxidant defense molecules were monitored in 59 women undergoing a year treatment for cancer. RESULTS: During treatment, levels vitamin C glutathione decreased, while both malondialdehyde protein carbonyl products increased. Vitamin E affected smaller extent. The patients grouped by principal component analysis using their stress pro?les according time 95.9% total variance was explained first three components. CONCLUSION: pro?le population modified extensively during one exposure antineoplastic drugs.